Identification and characterization of a strong constitutive promoter stnYp for activating biosynthetic genes and producing natural products in streptomyces.

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作者： Wenli,Guo ^[1] ; Zhihong,Xiao ^[1] ; Tingting,Huang ^[1] ; Kai,Zhang ^[2] ; Hai-Xue,Pan ^[3] ; Gong-Li,Tang ^[3] ; Zixin,Deng ^[3] ; Rubing,Liang ^[1] ; Shuangjun,Lin ^[2]

作者单位： State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory on Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China. ^[1] Haihe Laboratory of Synthetic Biology, Tianjin, 300308, China. ^[2] State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200032, China. ^[3] State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory on Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China. icelike@sjtu.edu.cn. ^[4] Haihe Laboratory of Synthetic Biology, Tianjin, 300308, China. icelike@sjtu.edu.cn. ^[5] State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory on Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China. linsj@sjtu.edu.cn. ^[6] Haihe Laboratory of Synthetic Biology, Tianjin, 300308, China. linsj@sjtu.edu.cn. ^[7] Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China. linsj@sjtu.edu.cn. ^[8]

关键词 Biosynthetic gene cluster Constitutive promoter Heterologous expression Natural products Streptomyces stnYp

主题词泰乐菌素(Tylosin);生物制品(Biological Products);链霉菌属(Streptomyces);启动区, 遗传(Promoter Regions, Genetic);多基因族(Multigene Family)

DOI 10.1186/s12934-023-02136-9

PMID 37443029

发布时间 2023-07-18

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