首页> International journal of molecular sciences> GSK-3 Inhibitor Elraglusib Enhances Tumor-Infiltrating Immune Cell Activation in Tumor Biopsies and Synergizes with Anti-PD-L1 in a Murine Model of Colorectal Cancer.

GSK-3 Inhibitor Elraglusib Enhances Tumor-Infiltrating Immune Cell Activation in Tumor Biopsies and Synergizes with Anti-PD-L1 in a Murine Model of Colorectal Cancer.

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第一作者： Kelsey E,Huntington

第一单位： Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA.;Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Brown University, Providence, RI 02903, USA.;The Joint Program in Cancer Biology, Lifespan Health System, Brown University, Providence, RI 02903, USA.;Legorreta Cancer Center, Brown University, Providence, RI 02903, USA.;Pathobiology Graduate Program, Brown University, Providence, RI 02903, USA.

作者： Kelsey E,Huntington ^[1] ; Anna D,Louie ^[2] ; Praveen R,Srinivasan ^[3] ; Christoph,Schorl ^[4] ; Shaolei,Lu ^[5] ; David,Silverberg ^[6] ; Daniel,Newhouse ^[7] ; Zhijin,Wu ^[8] ; Lanlan,Zhou ^[3] ; Brittany A,Borden ^[9] ; Francis J,Giles ^[10] ; Mark,Dooner ^[11] ; Benedito A,Carneiro ^[12] ; Wafik S,El-Deiry ^[13]

作者单位： Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA.;Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Brown University, Providence, RI 02903, USA.;The Joint Program in Cancer Biology, Lifespan Health System, Brown University, Providence, RI 02903, USA.;Legorreta Cancer Center, Brown University, Providence, RI 02903, USA.;Pathobiology Graduate Program, Brown University, Providence, RI 02903, USA. ^[1] Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA.;Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Brown University, Providence, RI 02903, USA.;The Joint Program in Cancer Biology, Lifespan Health System, Brown University, Providence, RI 02903, USA.;Legorreta Cancer Center, Brown University, Providence, RI 02903, USA.;Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.;Department of Surgery, Lifespan Health System, Providence, RI 02903, USA. ^[2] Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA.;Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Brown University, Providence, RI 02903, USA.;The Joint Program in Cancer Biology, Lifespan Health System, Brown University, Providence, RI 02903, USA.;Legorreta Cancer Center, Brown University, Providence, RI 02903, USA.;Warren Alpert Medical School, Brown University, Providence, RI 02903, USA. ^[3] Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.;Genomics Core Facility, Brown University, Providence, RI 02903, USA.;Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02903, USA. ^[4] Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA.;The Joint Program in Cancer Biology, Lifespan Health System, Brown University, Providence, RI 02903, USA.;Legorreta Cancer Center, Brown University, Providence, RI 02903, USA.;Warren Alpert Medical School, Brown University, Providence, RI 02903, USA. ^[5] Molecular Pathology Core Facility, Brown University, Providence, RI 02903, USA. ^[6] NanoString Technologies, Seattle, WA 98109, USA. ^[7] Department of Biostatistics, Brown University, Providence, RI 02903, USA. ^[8] Warren Alpert Medical School, Brown University, Providence, RI 02903, USA. ^[9] Developmental Therapeutics LLC, Chicago, IL 60611, USA. ^[10] Division of Hematology/Oncology, Department of Medicine, Lifespan Health System, Providence, RI 02903, USA. ^[11] The Joint Program in Cancer Biology, Lifespan Health System, Brown University, Providence, RI 02903, USA.;Legorreta Cancer Center, Brown University, Providence, RI 02903, USA.;Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.;Division of Hematology/Oncology, Department of Medicine, Lifespan Health System, Providence, RI 02903, USA. ^[12] Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA.;Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Brown University, Providence, RI 02903, USA.;The Joint Program in Cancer Biology, Lifespan Health System, Brown University, Providence, RI 02903, USA.;Legorreta Cancer Center, Brown University, Providence, RI 02903, USA.;Pathobiology Graduate Program, Brown University, Providence, RI 02903, USA.;Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.;Division of Hematology/Oncology, Department of Medicine, Lifespan Health System, Providence, RI 02903, USA. ^[13]

关键词 9-ING-41 GSK-3 elraglusib immune checkpoint blockade immunotherapy