DeepTAP: An RNN-based method of TAP-binding peptide prediction in the selection of tumor neoantigens.

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第一作者： Xue,Zhang

第一单位： National Key Laboratory of Advanced Drug Delivery and Release Systems & Zhejiang Provincial Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.

作者： Xue,Zhang ^[1] ; Jingcheng,Wu ^[1] ; Joseph,Baeza ^[2] ; Katie,Gu ^[3] ; Yichun,Zheng ^[4] ; Shuqing,Chen ^[5] ; Zhan,Zhou ^[6]

作者单位： National Key Laboratory of Advanced Drug Delivery and Release Systems & Zhejiang Provincial Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. ^[1] Biology Program, Iowa State University, Ames, IA, 50011, USA. ^[2] Biology Program, Washington University in St. Louis, St. Louis, MO, 63130, USA. ^[3] The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, 322000, China. Electronic address: 2101090@zju.edu.cn. ^[4] National Key Laboratory of Advanced Drug Delivery and Release Systems & Zhejiang Provincial Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. Electronic address: chenshuqing@zju.edu.cn. ^[5] National Key Laboratory of Advanced Drug Delivery and Release Systems & Zhejiang Provincial Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China; The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, 322000, China; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China; Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou, 310058, China. Electronic address: zhanzhou@zju.edu.cn. ^[6]

关键词 Binding peptide Recurrent neural network (RNN)T-cell epitopes Transporter associated with antigen processing (TAP)Tumor neoantigens

主题词人类(Humans);抗原呈递(Antigen Presentation);ATP结合匣式转运子(ATP-Binding Cassette Transporters);肽类(Peptides);肿瘤(Neoplasms);表位, T淋巴细胞(Epitopes, T-Lymphocyte)

DOI 10.1016/j.compbiomed.2023.107247

PMID 37454505

发布时间 2023-09-11

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