Synthesis and characterization of the N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) alternate substrate analog N,N-dimethyl-l,l-SDAP.

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作者： Zachary J,Liveris ^[1] ; Emma H,Kelley ^[1] ; Emma,Simmons ^[1] ; Katherine,Konczak ^[1] ; Marlon R,Lutz ^[1] ; Miguel,Ballicora ^[1] ; Kenneth W,Olsen ^[1] ; Daniel P,Becker ^[2]

作者单位： Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, IL 60660, United States. ^[1] Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, IL 60660, United States. Electronic address: dbecke3@luc.edu. ^[2]

关键词 Alternate substrate Asymmetric synthesis DapE Diaminopimelate desuccinylase Enzyme assay Substrate analog

主题词人类(Humans);二胺基庚二酸(Diaminopimelic Acid);赖氨酸(Lysine);琥珀酸盐(Succinates);抗药性, 细菌(Drug Resistance, Bacterial)

DOI 10.1016/j.bmc.2023.117415

PMID 37459673

发布时间 2023-08-14

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