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Nitro-benzylideneoxymorphone, a bifunctional mu and delta opioid receptor ligand with high mu opioid receptor efficacy.

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第一作者： Keith M,Olson

第一单位： Department of Pharmacology and Edward F. Domino Research Center, University of Michigan Medical School, Ann Arbor, MI, United States.

作者： Keith M,Olson ^[1] ; Andrea L,Devereaux ^[2] ; Payal,Chatterjee ^[3] ; Savanah L,Saldaña-Shumaker ^[2] ; Amanda,Shafer ^[1] ; Adam,Plotkin ^[2] ; Ram,Kandasamy ^[4] ; Alexander D,MacKerell ^[3] ; John R,Traynor ^[5] ; Christopher W,Cunningham ^[2]

作者单位： Department of Pharmacology and Edward F. Domino Research Center, University of Michigan Medical School, Ann Arbor, MI, United States. ^[1] Department of Pharmaceutical Sciences, Concordia University Wisconsin School of Pharmacy, Mequon, WI, United States. ^[2] Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, United States. ^[3] Department of Pharmacology and Edward F. Domino Research Center, University of Michigan Medical School, Ann Arbor, MI, United States.;Department of Psychology, California State University, East Bay, Hayward, CA, United States. ^[4] Department of Pharmacology and Edward F. Domino Research Center, University of Michigan Medical School, Ann Arbor, MI, United States.;Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, United States. ^[5]

关键词 SILCS bifunctional analgesics delta opioid receptor dependence mu opioid receptor tolerance

DOI 10.3389/fphar.2023.1230053

PMID 37469877

发布时间 2025-06-13

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