Simultaneous estimation of five biomarkers of neuroprotective herb Ashwagandha NMITLI-118R AF1 in rat plasma and brain using LC-ESI-MS/MS: Application to its pharmacokinetic and stability studies.

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第一作者： Shailesh D,Dadge

第一单位： Pharmaceutics & Pharmacokinetics, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.

作者： Shailesh D,Dadge ^[1] ; Neerja,Tiwari ^[2] ; Athar,Husain ^[1] ; Saurabh,Verma ^[1] ; Arun,Agarwal ^[1] ; Richa,Garg ^[1] ; Srikanta K,Rath ^[3] ; Karuna,Shanker ^[4] ; Jiaur R,Gayen ^[5]

作者单位： Pharmaceutics & Pharmacokinetics, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. ^[1] Department of Analytical Chemistry, CSIR-Central Institute of Medicinal and Aromatic Plants, Picnic Spot Road, Lucknow 226015, India. ^[2] Toxicology & Experimental Medicine, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. ^[3] Department of Analytical Chemistry, CSIR-Central Institute of Medicinal and Aromatic Plants, Picnic Spot Road, Lucknow 226015, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. ^[4] Pharmaceutics & Pharmacokinetics, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow 226031, India; Pharmacology Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: jr.gayen@cdri.res.in. ^[5]

关键词 ADME Bioanalytical LC-MS/MS Pharmacokinetics Stability WS

主题词大鼠(Rats);动物(Animals);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);串联质谱法(Tandem Mass Spectrometry);睡茄属(Withania);大鼠, 近交WF(Rats, Inbred WF);植物提取物(Plant Extracts);脑(Brain);结果可重复性(Reproducibility of Results);色谱法, 高压液相(Chromatography, High Pressure Liquid)

DOI 10.1016/j.jchromb.2023.123834

PMID 37481788

发布时间 2023-09-12

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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2023年1228卷

123834页

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Simultaneous estimation of five biomarkers of neuroprotective herb Ashwagandha NMITLI-118R AF1 in rat plasma and brain using LC-ESI-MS/MS: Application to its pharmacokinetic and stability studies.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

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Simultaneous estimation of five biomarkers of neuroprotective herb Ashwagandha NMITLI-118R AF1 in rat plasma and brain using LC-ESI-MS/MS: Application to its pharmacokinetic and stability studies.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

相似文献

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

相关期刊

检索历史清除