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Human IP<sub>3</sub> receptor triple knockout stem cells remain pluripotent despite altered mitochondrial metabolism.

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第一作者： Julius,Rönkkö

第一单位： Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, 00290, Finland.

作者： Julius,Rönkkö ^[1] ; Yago,Rodriguez ^[1] ; Tiina,Rasila ^[1] ; Rubén,Torregrosa-Muñumer ^[1] ; Jana,Pennonen ^[1] ; Jouni,Kvist ^[1] ; Emilia,Kuuluvainen ^[2] ; Ludo Van Den,Bosch ^[3] ; Ville,Hietakangas ^[2] ; Geert,Bultynck ^[4] ; Henna,Tyynismaa ^[1] ; Emil,Ylikallio ^[5]

作者单位： Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, 00290, Finland. ^[1] Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, 00790, Finland; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, 00790, Finland. ^[2] Department of Neurosciences, Experimental Neurology and Leuven Brain Institute, KU Leuven - University of Leuven, 3000, Leuven, Belgium; VIB Center for Brain & Disease Research, Laboratory of Neurobiology, 3000, Leuven, Belgium. ^[3] KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine & Leuven Kanker Instituut, Leuven, 3000, Belgium. ^[4] Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, 00290, Finland; Clinical Neurosciences, Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, 00290, Finland. Electronic address: emil.ylikallio@helsinki.fi. ^[5]

关键词 Ca(2+) signaling IP(3)R1 IP(3)R2 IP(3)R3 Induced pluripotent stem cells Inositol 1,4,5-trisphosphate receptors Mitochondria TCA iPSC

医学主题词人类(Humans);肌醇1,4,5-三磷酸受体(Inositol 1,4,5-Trisphosphate Receptors);线粒体(Mitochondria);诱导多能干细胞(Induced Pluripotent Stem Cells);基因敲除技术(Gene Knockout Techniques);柠檬酸循环(Citric Acid Cycle)

DOI 10.1016/j.ceca.2023.102782

PMID 37481871

发布时间 2026-06-11

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