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Pattern recognition receptor agonists in pathogen vaccines mediate antitumor T-cell cross-priming.

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第一作者： Mark,Aleynick

第一单位： Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.;Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.;Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

作者： Mark,Aleynick ^[1] ; Judit,Svensson-Arvelund ^[2] ; Gvantsa,Pantsulaia ^[2] ; Kristy,Kim ^[2] ; Samuel A,Rose ^[3] ; Ranjan,Upadhyay ^[1] ; Michael,Yellin ^[4] ; Henry,Marsh ^[4] ; Daniel,Oreper ^[5] ; Suchit,Jhunjhunwala ^[5] ; Christine Carine,Moussion ^[5] ; Miriam,Merad ^[6] ; Brian D,Brown ^[6] ; Joshua D,Brody ^[7]

作者单位： Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.;Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.;Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. ^[1] Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.;Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. ^[2] Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.;Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. ^[3] Celldex Therapeutics Inc, Hampton, New Jersey, USA. ^[4] Genentech Inc, South San Francisco, California, USA. ^[5] Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. ^[6] Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA joshua.brody@mssm.edu.;Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. ^[7]

关键词 Adjuvants, Immunologic Antigen Presentation Dendritic Cells Immunotherapy, Active Vaccination

医学主题词人类(Humans);动物(Animals);小鼠(Mice);交叉激活(Cross-Priming);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);接种(Vaccination);免疫法(Immunization)

DOI 10.1136/jitc-2023-007198

PMID 37487664

发布时间 2023-07-29

基金项目

R37 CA246239/CA/NCI NIH HHS/United States R33 CA223947/CA/NCI NIH HHS/United States R01 CA257195/CA/NCI NIH HHS/United States R01 CA254104/CA/NCI NIH HHS/United States R01 AT011326/AT/NCCIH NIH HHS/United States

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Journal for immunotherapy of cancer

2023年11卷7期

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Journal for immunotherapy of cancer

2023年11卷7期

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Pattern recognition receptor agonists in pathogen vaccines mediate antitumor T-cell cross-priming.

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Pattern recognition receptor agonists in pathogen vaccines mediate antitumor T-cell cross-priming.

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

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