Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia.

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作者： Qian,Chen ^[1] ; Jiexing,He ^[1] ; Haihua,Liu ^[1] ; Qiuyu,Huang ^[1] ; Shuoshi,Wang ^[2] ; Ailan,Yin ^[1] ; Shuying,Chen ^[3] ; Xinyang,Shen ^[1] ; Yanxuan,Xiao ^[1] ; Haoyue,Hu ^[1] ; Jiayi,Jiang ^[1] ; Wenqian,Chen ^[1] ; Song,Wang ^[1] ; Zhenqin,Huang ^[1] ; Jiaqi,Li ^[1] ; You,Peng ^[1] ; Xiaocong,Wang ^[1] ; Xinping,Yang ^[4] ; Zhijian,Wang ^[5] ; Mei,Zhong ^[6]

作者单位： Department of Obstetrics & Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. ^[1] Department of Obstetrics, Shenzhen People's Hospital, (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, China. ^[2] Department of Obstetrics, Shenzhen Second People's Hospital, Shenzhen University 1st Affiliated Hospital, Shenzhen, 518035, China. ^[3] Department of Obstetrics & Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. xpyang1@smu.edu.cn. ^[4] Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, 510515, China. xpyang1@smu.edu.cn. ^[5] Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. xpyang1@smu.edu.cn. ^[6] Department of Obstetrics & Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. wzjnfyy@163.com. ^[7] Department of Obstetrics & Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. zhongmei@smu.edu.cn. ^[8]

关键词 Advanced oxidation protein products DDIT4 Extracellular vesicles Oxidative stress PDIA4 Preeclampsia Pyroptosis TDRKH-AS1 lncRNA