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Ionization detail parameters and cluster dose: a mathematical model for selection of nanodosimetric quantities for use in treatment planning in charged particle radiotherapy.

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第一作者： Bruce,Faddegon

第一单位： University of California San Francisco, Department of Radiation Oncology 1600 Divisadero Street, San Francisco, CA 94143 United States of America.

作者： Bruce,Faddegon ^[1] ; Eleanor A,Blakely ^[2] ; Lucas,Burigo ^[3] ; Yair,Censor ^[4] ; Ivana,Dokic ^[5] ; Naoki,Domínguez Kondo ^[1] ; Ramon,Ortiz ^[1] ; José,Ramos Méndez ^[1] ; Antoni,Rucinski ^[6] ; Keith,Schubert ^[7] ; Niklas,Wahl ^[3] ; Reinhard,Schulte ^[8]

作者单位： University of California San Francisco, Department of Radiation Oncology 1600 Divisadero Street, San Francisco, CA 94143 United States of America. ^[1] Loma Linda University School of Medicine, 11175 Campus St, Loma Linda, CA 92350, United States of America. ^[2] Division of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.;National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany. ^[3] Department of Mathematics, University of Haifa, 199 Aba Khoushy Ave. Mount Carmel, Haifa, 3498838, Israel. ^[4] Clinical Cooperation Unit Translational Radiation Oncology, German Cancer Consortium (DKTK) Core-Center Heidelberg, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.;Division of Molecular and Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany.;Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University Hospital and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. ^[5] Institute of Nuclear Physics Polish Academy of Sciences, Radzikowskiego 152, 31-342 Kraków, Poland. ^[6] Baylor University, 1311 S 5th St, Waco, TX 76706, United States of America. ^[7] Loma Linda University School of Medicine, 11085 Campus St, Loma Linda, CA 92350, United States of America. ^[8]

关键词 RBE nanodosimetry particle therapy track structure simulation treatment planning

医学主题词相对生物学效应(Relative Biological Effectiveness);细胞系(Cell Line);放射肿瘤学(Radiation Oncology);质子(Protons);模型, 生物学(Models, Biological)

DOI 10.1088/1361-6560/acea16

PMID 37489619

发布时间 2025-09-06

基金项目

P20 CA183640/CA/NCI NIH HHS/United States R01 CA266467/CA/NCI NIH HHS/United States

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