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Error-corrected duplex sequencing enables direct detection and quantification of mutations in human TK6 cells with strong inter-laboratory consistency.

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第一作者： Eunnara,Cho

第一单位： Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada; Department of Biology, Carleton University, Ottawa, ON, Canada.

作者： Eunnara,Cho ^[1] ; Carol D,Swartz ^[2] ; Andrew,Williams ^[3] ; Miriam,V Rivas ^[2] ; Leslie,Recio ^[4] ; Kristine L,Witt ^[5] ; Elizabeth K,Schmidt ^[6] ; Jeffry,Yaplee ^[6] ; Thomas H,Smith ^[6] ; Phu,Van ^[6] ; Fang Yin,Lo ^[6] ; Charles C,Valentine ^[6] ; Jesse J,Salk ^[6] ; Francesco,Marchetti ^[1] ; Stephanie L,Smith-Roe ^[7] ; Carole L,Yauk ^[8]

作者单位： Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada; Department of Biology, Carleton University, Ottawa, ON, Canada. ^[1] Inotiv-RTP, Research Triangle Park, NC, USA. ^[2] Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada. ^[3] Inotiv-RTP, Research Triangle Park, NC, USA; Scitovation, Research Triangle Park, NC, USA. ^[4] Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. ^[5] TwinStrand Biosciences, Inc., Seattle, WA, USA. ^[6] Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Electronic address: stephanie.smith-roe@nih.gov. ^[7] Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada; Department of Biology, Carleton University, Ottawa, ON, Canada; Department of Biology, University of Ottawa, Ottawa, ON, Canada. Electronic address: Carole.Yauk@uottawa.ca. ^[8]

关键词 Error-corrected next-generation sequencing In vitro Mutagenesis Mutation spectrum N-ethyl-N-nitrosourea

医学主题词人类(Humans);结果可重复性(Reproducibility of Results);突变(Mutation);诱变剂(Mutagens);诱变(Mutagenesis);DNA(DNA);乙基亚硝脲(Ethylnitrosourea)

DOI 10.1016/j.mrgentox.2023.503649

PMID 37491114

发布时间 2025-05-30

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准确一般字义偏差语意偏离译文作用小提交