A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant.

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作者： Stephen J,Pettitt ^[1] ; Nan,Shao ^[2] ; Diana,Zatreanu ^[2] ; Jessica,Frankum ^[2] ; Ilirjana,Bajrami ^[2] ; Rachel,Brough ^[2] ; Dragomir B,Krastev ^[2] ; Theodoros I,Roumeliotis ^[3] ; Jyoti S,Choudhary ^[3] ; Sonja,Lorenz ^[4] ; Alistair,Rust ^[3] ; Johann S,de Bono ^[5] ; Timothy A,Yap ^[5] ; Andrew N J,Tutt ^[6] ; Christopher J,Lord ^[7]

作者单位： The CRUK Gene Function Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK. Stephen.Pettitt@icr.ac.uk. ^[1] The CRUK Gene Function Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK. ^[2] The Institute of Cancer Research, London, SW3 6JB, UK. ^[3] Max Planck Institute for Multidisciplinary Sciences, 37077, Göttingen, Germany. ^[4] The Institute of Cancer Research, The Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK. ^[5] University of Texas MD Anderson Cancer Center, 1400 Holcombe Blvd, Houston, TX, 77030, USA. ^[6] The CRUK Gene Function Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK. Andrew.Tutt@icr.ac.uk. ^[7] The CRUK Gene Function Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK. Chris.Lord@icr.ac.uk. ^[8]