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Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies.

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作者单位: Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany. [1] Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.;Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany. [2] Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.;NeuroImaging Core Unit Munich (NICUM), LMU University Hospital, LMU Munich, Munich, Germany. [3] Institute for Stroke and Dementia Research, Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.;Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden. [4] Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Department of Neurology, LMU University Hospital, LMU Munich, Munich, Germany. [5] German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Department of Neurology, LMU University Hospital, LMU Munich, Munich, Germany. [6] Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany. [7] Department of Psychiatry and Psychotherapy, University Regensburg, Regensburg, Germany. [8] Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.;Department of Nuclear Medicine, University Hospital, Inselspital Bern, Bern, Switzerland. [9] Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.;Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany. [10] Department of Psychiatry and Psychotherapy, Klinikum Rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany. [11] Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, Augsburg, Germany. [12] Institute for Stroke and Dementia Research, Munich, Germany. [13] NeuroImaging Core Unit Munich (NICUM), LMU University Hospital, LMU Munich, Munich, Germany.;Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany. [14] Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany. [15] German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. [16] Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany. [17] Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. [18] Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Institute of Neuronal Cell Biology, Technical University of Munich, Munich, Germany. [19] Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Munich, Germany. [20] German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Department of Neurology, LMU University Hospital, LMU Munich, Munich, Germany.;Department of Neurology, Hannover Medical School, Hannover, Germany. [21] Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany.;Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, UK.;Sheffield Institute for Translational Neurosciences (SITraN), University of Sheffield, Sheffield, UK. [22] Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany. matthias.brendel@med.uni-muenchen.de.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. matthias.brendel@med.uni-muenchen.de.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. matthias.brendel@med.uni-muenchen.de. [23]
DOI 10.1038/s41380-023-02188-8
PMID 37495886
发布时间 2024-10-23
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