Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies.
作者:
Anika,Finze [1]
;
Gloria,Biechele [2]
;
Boris-Stephan,Rauchmann [3]
;
Nicolai,Franzmeier [4]
;
Carla,Palleis [5]
;
Sabrina,Katzdobler [5]
;
Endy,Weidinger [6]
;
Selim,Guersel [7]
;
Sebastian,Schuster [1]
;
Stefanie,Harris [1]
;
Julia,Schmitt [1]
;
Leonie,Beyer [1]
;
Johannes,Gnörich [1]
;
Simon,Lindner [1]
;
Nathalie L,Albert [1]
;
Christian H,Wetzel [8]
;
Rainer,Rupprecht [8]
;
Axel,Rominger [9]
;
Adrian,Danek [6]
;
Lena,Burow [7]
;
Carolin,Kurz [7]
;
Maia,Tato [7]
;
Julia,Utecht [7]
;
Boris,Papazov [3]
;
Mirlind,Zaganjori [10]
;
Lena-Katharina,Trappmann [7]
;
Oliver,Goldhardt [11]
;
Timo,Grimmer [11]
;
Jan,Haeckert [12]
;
Daniel,Janowitz [13]
;
Katharina,Buerger [13]
;
Daniel,Keeser [14]
;
Sophia,Stoecklein [15]
;
Olaf,Dietrich [15]
;
Estrella,Morenas-Rodriguez [16]
;
Henryk,Barthel [17]
;
Osama,Sabri [17]
;
Peter,Bartenstein [18]
;
Mikael,Simons [19]
;
Christian,Haass [20]
;
Günter U,Höglinger [21]
;
Johannes,Levin [5]
;
Robert,Perneczky [22]
;
Matthias,Brendel [23]
作者单位:
Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
[1]
Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.;Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.
[2]
Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.;NeuroImaging Core Unit Munich (NICUM), LMU University Hospital, LMU Munich, Munich, Germany.
[3]
Institute for Stroke and Dementia Research, Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.;Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
[4]
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Department of Neurology, LMU University Hospital, LMU Munich, Munich, Germany.
[5]
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Department of Neurology, LMU University Hospital, LMU Munich, Munich, Germany.
[6]
Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany.
[7]
Department of Psychiatry and Psychotherapy, University Regensburg, Regensburg, Germany.
[8]
Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.;Department of Nuclear Medicine, University Hospital, Inselspital Bern, Bern, Switzerland.
[9]
Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.;Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany.
[10]
Department of Psychiatry and Psychotherapy, Klinikum Rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany.
[11]
Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, Augsburg, Germany.
[12]
Institute for Stroke and Dementia Research, Munich, Germany.
[13]
NeuroImaging Core Unit Munich (NICUM), LMU University Hospital, LMU Munich, Munich, Germany.;Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany.
[14]
Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.
[15]
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
[16]
Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
[17]
Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
[18]
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Institute of Neuronal Cell Biology, Technical University of Munich, Munich, Germany.
[19]
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Munich, Germany.
[20]
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Department of Neurology, LMU University Hospital, LMU Munich, Munich, Germany.;Department of Neurology, Hannover Medical School, Hannover, Germany.
[21]
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany.;Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, UK.;Sheffield Institute for Translational Neurosciences (SITraN), University of Sheffield, Sheffield, UK.
[22]
Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany. matthias.brendel@med.uni-muenchen.de.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. matthias.brendel@med.uni-muenchen.de.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. matthias.brendel@med.uni-muenchen.de.
[23]
主题词
人类(Humans);小神经胶质细胞(Microglia);阿尔茨海默病(Alzheimer Disease);Tau病变(Tauopathies);淀粉样β肽类(Amyloid beta-Peptides);萎缩(Atrophy);tau蛋白质类(tau Proteins);受体, GABA(Receptors, GABA)
DOI
10.1038/s41380-023-02188-8
PMID
37495886
发布时间
2024-10-23
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Molecular psychiatry
Molecular psychiatry
4438-4450页
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