Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques.
作者:
Elise G,Viox [1]
;
Timothy N,Hoang [1]
;
Amit A,Upadhyay [1]
;
Rayhane,Nchioua [2]
;
Maximilian,Hirschenberger [2]
;
Zachary,Strongin [1]
;
Gregory K,Tharp [3]
;
Maria,Pino [1]
;
Kevin,Nguyen [1]
;
Justin L,Harper [1]
;
Matthew,Gagne [4]
;
Shir,Marciano [5]
;
Arun K,Boddapati [3]
;
Kathryn L,Pellegrini [3]
;
Arpan,Pradhan [1]
;
Jennifer,Tisoncik-Go [6]
;
Leanne S,Whitmore [6]
;
Kirti A,Karunakaran [1]
;
Melissa,Roy [7]
;
Shannon,Kirejczyk [8]
;
Elizabeth H,Curran [7]
;
Chelsea,Wallace [9]
;
Jennifer S,Wood [9]
;
Fawn,Connor-Stroud [9]
;
Emily A,Voigt [10]
;
Christopher M,Monaco [11]
;
David E,Gordon [11]
;
Sudhir P,Kasturi [12]
;
Rebecca D,Levit [13]
;
Michael,Gale [6]
;
Thomas H,Vanderford [1]
;
Guido,Silvestri [12]
;
Kathleen,Busman-Sahay [14]
;
Jacob D,Estes [15]
;
Monica,Vaccari [16]
;
Daniel C,Douek [4]
;
Konstantin M J,Sparrer [2]
;
R Paul,Johnson [17]
;
Frank,Kirchhoff [2]
;
Gideon,Schreiber [5]
;
Steven E,Bosinger [18]
;
Mirko,Paiardini [12]
作者单位:
Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
[1]
Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
[2]
Emory NPRC Genomics Core Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
[3]
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
[4]
Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
[5]
Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
[6]
Division of Pathology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
[7]
StageBio, 5930 Main St., Mount Jackson, VA 22842, USA.
[8]
Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
[9]
RNA Vaccines Group, Access to Advanced Health Institute, Seattle, WA 98102, USA.
[10]
Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
[11]
Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.;Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
[12]
Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
[13]
Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
[14]
Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.;Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.;Department of Clinical Medicine, Aarhus University, Aarhus 8000, Denmark.;School of Health and Biomedical Sciences, College of Science, Engineering and Health, RMIT University, Melbourne, VIC 3000, Australia.
[15]
Division of Immunology, Tulane National Primate Research Center, Covington, LA 70433, USA.;Department of Microbiology and Immunology, Tulane School of Medicine, New Orleans, LA 70112, USA.
[16]
Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.;Infectious Disease Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
[17]
Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.;Emory NPRC Genomics Core Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.;Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
[18]
主题词
动物(Animals);干扰素Ⅰ型(Interferon Type I);猕猴(Macaca mulatta);病毒复制(Virus Replication);抗病毒药(Antiviral Agents);炎症(Inflammation)
DOI
10.1126/sciimmunol.adg0033
PMID
37506197
发布时间
2024-11-01
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Science immunology
Science immunology
2023年8卷85期
eadg0033页
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