首页> The Journal of allergy and clinical immunology> Single-cell profiling of prurigo nodularis demonstrates immune-stromal crosstalk driving profibrotic responses and reversal with nemolizumab.

Single-cell profiling of prurigo nodularis demonstrates immune-stromal crosstalk driving profibrotic responses and reversal with nemolizumab.

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第一作者： Feiyang,Ma

第一单位： Department of Dermatology, University of Michigan, Ann Arbor, Mich.

作者： Feiyang,Ma ^[1] ; Mehrnaz,Gharaee-Kermani ^[1] ; Lam C,Tsoi ^[2] ; Olesya,Plazyo ^[1] ; Prasad,Chaskar ^[3] ; Paul,Harms ^[4] ; Matthew T,Patrick ^[1] ; Xianying,Xing ^[1] ; Grace,Hile ^[1] ; Christophe,Piketty ^[3] ; Anne,Lazzari ^[3] ; Wouter,Van Delm ^[3] ; Emanual,Maverakis ^[5] ; Mio,Nakamura ^[1] ; Robert L,Modlin ^[6] ; J Michelle,Kahlenberg ^[7] ; Allison C,Billi ^[1] ; Valerie,Julia ^[3] ; Jayendra Kumar,Krishnaswamy ^[3] ; Johann E,Gudjonsson ^[8]

作者单位： Department of Dermatology, University of Michigan, Ann Arbor, Mich. ^[1] Department of Dermatology, University of Michigan, Ann Arbor, Mich; Department of Biostatistics, University of Michigan, Ann Arbor, Mich; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Mich. ^[2] Galderma, Lausanne, Switzerland. ^[3] Department of Dermatology, University of Michigan, Ann Arbor, Mich; Department of Pathology, University of Michigan, Ann Arbor, Mich. ^[4] Department of Dermatology, University of California-Davis, Sacramento, Calif. ^[5] Department of Dermatology, University of California-Los Angeles, Calif. ^[6] Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Mich; Taubman Medical Research Institute, University of Michigan, Ann Arbor, Mich. ^[7] Department of Dermatology, University of Michigan, Ann Arbor, Mich; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Mich; Taubman Medical Research Institute, University of Michigan, Ann Arbor, Mich. Electronic address: johanng@med.umich.edu. ^[8]

关键词 Prurigo nodularis fibrosis inflammation nemolizumab single-cell RNA-sequencing spatial-sequencing

医学主题词人类(Humans);痒疹(Prurigo);皮炎, 特应性(Dermatitis, Atopic);皮肤(Skin);慢性病(Chronic Disease);RNA(RNA);瘙痒症(Pruritus)

DOI 10.1016/j.jaci.2023.07.005

PMID 37506977

发布时间 2025-07-22

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