Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain.

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作者： Nathaniel E,Clark ^[1] ; Adam,Katolik ^[2] ; Pascal,Gallant ^[2] ; Anastasia,Welch ^[3] ; Eileen,Murphy ^[3] ; Luke,Buerer ^[3] ; Christoph,Schorl ^[3] ; Nandita,Naik ^[3] ; Mandar T,Naik ^[3] ; Stephen P,Holloway ^[4] ; Kristin,Cano ^[4] ; Susan T,Weintraub ^[4] ; Katherine M,Howard ^[5] ; P John,Hart ^[4] ; Gerwald,Jogl ^[3] ; Masad J,Damha ^[6] ; William G,Fairbrother ^[7]

作者单位： Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, USA. Electronic address: nathanielclar5@gmail.com. ^[1] Department of Chemistry, McGill University, Montreal, Quebec, Canada. ^[2] Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, USA. ^[3] Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, USA. ^[4] Department of Biomedical Sciences, School of Dental Medicine, University of Nevada-Las Vegas, Las Vegas, Nevada, USA. ^[5] Department of Chemistry, McGill University, Montreal, Quebec, Canada. Electronic address: masad_damha@mcgill.ca. ^[6] Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, USA. Electronic address: william_fairbrother@brown.edu. ^[7]

关键词 RNA branched RNA crystal structure debranching enzyme introns lariats metalloenzymes metallophosphodiesterase phosphorothioate