Clinical trio genome sequencing facilitates the interpretation of variants in cancer predisposition genes in paediatric tumour patients.

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作者： Christopher,Schroeder ^[1] ; Ulrike,Faust ^[2] ; Luisa,Krauße ^[1] ; Alexandra,Liebmann ^[1] ; Michael,Abele ^[1] ; German,Demidov ^[3] ; Leon,Schütz ^[1] ; Olga,Kelemen ^[1] ; Alexandra,Pohle ^[1] ; Silja,Gauß ^[1] ; Marc,Sturm ^[1] ; Cristiana,Roggia ^[1] ; Monika,Streiter ^[1] ; Rebecca,Buchert ^[4] ; Sorin,Armenau-Ebinger ^[1] ; Dominik,Nann ^[1] ; Rudi,Beschorner ^[5] ; Rupert,Handgretinger ^[5] ; Martin,Ebinger ^[3] ; Peter,Lang ^[3] ; Ursula,Holzer ^[3] ; Julia,Skokowa ^[3] ; Stephan,Ossowski ^[6] ; Tobias B,Haack ^[1] ; Ulrike A,Mau-Holzmann ^[1] ; Andreas,Dufke ^[1] ; Olaf,Riess ^[1] ; Ines B,Brecht ^[1]

作者单位： Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen, Tübingen, Germany. ^[1] Centre for Personalized Cancer Prevention, University Hospital Tübingen, Tübingen, Germany. ^[2] Department of Paediatric Haematology and Oncology, University Children's Hospital Tübingen, Tübingen, Germany. ^[3] Department of Paediatric Haematology and Oncology, Children's Hospital Heilbronn, Heilbronn, Germany. ^[4] Institute of Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany. ^[5] Department of Oncology, Haematology, Immunology, Rheumatology, and Pulmonology, University Hospital Tübingen, Tübingen, Germany. ^[6] NGS Core Centre Tübingen, University Tübingen, Tübingen, Germany. ^[7] Department of Paediatric Haematology and Oncology, University Children's Hospital Tübingen, Tübingen, Germany. ines.brecht@med.uni-tuebingen.de. ^[8]