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Proteomics reveals a global phenotypic shift of NK cells in HCV patients treated with direct-acting antivirals.

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第一作者： Wenjie,Bi

第一单位： Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, P. R. China.;Cellular Proteome Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany.

作者： Wenjie,Bi ^[1] ; Anke,Kraft ^[2] ; Sophie,Engelskircher ^[3] ; Jasmin,Mischke ^[2] ; Moana,Witte ^[3] ; Frank,Klawonn ^[4] ; Marco,van Ham ^[5] ; Markus,Cornberg ^[2] ; Heiner,Wedemeyer ^[6] ; Julia,Hengst ^[7] ; Lothar,Jänsch ^[5]

作者单位： Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, P. R. China.;Cellular Proteome Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany. ^[1] Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School (MHH), Hannover, Germany.;Centre for Individualised Infection Medicine (CiiM), A Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany.;German Centre for Infection Research (DZIF), Partner site Hannover-Braunschweig, Hannover, Germany.;TWINCORE, A Joint Venture Between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany. ^[2] Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School (MHH), Hannover, Germany.;Centre for Individualised Infection Medicine (CiiM), A Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany. ^[3] Cellular Proteome Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany.;Department of Computer Science, Ostfalia University, Wolfenbüttel, Germany. ^[4] Cellular Proteome Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany. ^[5] Centre for Individualised Infection Medicine (CiiM), A Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany.;German Centre for Infection Research (DZIF), Partner site Hannover-Braunschweig, Hannover, Germany.;Cluster of Excellence Resolving Infection Susceptibility (RESIST; EXC 2155), Hannover Medical School, Hannover, Germany. ^[6] Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School (MHH), Hannover, Germany. ^[7]

关键词 Direct-acting antivirals HCV NK cells NK-cell memory Proteomics

医学主题词人类(Humans);抗病毒药(Antiviral Agents);丙型肝炎, 慢性(Hepatitis C, Chronic);蛋白质组学(Proteomics);杀伤细胞, 天然(Killer Cells, Natural);表型(Phenotype);肝炎病毒属(Hepacivirus)

DOI 10.1002/eji.202250291

PMID 37515498

发布时间 2023-11-15

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