Differential responses of pulmonary vascular cells from PAH patients and controls to TNFα and the effect of the BET inhibitor JQ1.

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作者： Sharon,Mumby ^[1] ; Frederic,Perros ^[2] ; Julien,Grynblat ^[3] ; Gregoire,Manaud ^[2] ; Alberto,Papi ^[2] ; Paolo,Casolari ^[4] ; Gaetano,Caramori ^[4] ; Marc,Humbert ^[5] ; S,John Wort ^[2] ; Ian M,Adcock ^[6]

作者单位： Respiratory Science, NHLI, Imperial College London, London, UK. s.mumby@imperial.ac.uk. ^[1] Inserm UMR-S 999, Hôpital Marie Lannelongue, Groupe Hospitalier Paris Saint Joseph, Université Paris-Saclay, Le Plessis-Robinson, France. ^[2] CarMeN Laboratory, INSERM U1060, INRAE U1397, Université Claude Bernard Lyon1, Pierre-Bénite, France. ^[3] Interdepartmental Study Center for Inflammatory and Smoke-Related Airway Diseases, Cardiorespiratory and Internal Medicine Section, University of Ferrara, Ferrara, Italy. ^[4] Pneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e Delle Immagini Morfologiche e Funzionali (BIOMORF), Università Degli Studi di Messina, Messina, Italy. ^[5] Department of Respiratory and Intensive Care Medicine, AP-HP, Hôpital Bicêtre, Pulmonary Hypertension National Referral Center, Université Paris-Saclay, Le Kremlin-Bicêtre, France. ^[6] Respiratory Science, NHLI, Imperial College London, London, UK. ^[7] National Pulmonary Hypertension Service, Royal Brompton Hospital, London, UK. ^[8]

关键词 Bromodomain and extra‐terminal proteins Human pulmonary artery smooth muscle cells Human pulmonary microvascular endothelial cells Inflammation Pulmonary arterial hypertension