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Sex shapes cell-type-specific transcriptional signatures of stress exposure in the mouse hypothalamus.

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第一作者： Elena,Brivio

第一单位： Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany; International Max Planck Research School for Translational Psychiatry (IMPRS-TP), 80804 Munich, Germany; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.

作者： Elena,Brivio ^[1] ; Aron,Kos ^[2] ; Alessandro Francesco,Ulivi ^[3] ; Stoyo,Karamihalev ^[4] ; Andrea,Ressle ^[2] ; Rainer,Stoffel ^[2] ; Dana,Hirsch ^[5] ; Gil,Stelzer ^[6] ; Mathias V,Schmidt ^[7] ; Juan Pablo,Lopez ^[8] ; Alon,Chen ^[9]

作者单位： Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany; International Max Planck Research School for Translational Psychiatry (IMPRS-TP), 80804 Munich, Germany; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 76100, Israel. ^[1] Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany. ^[2] Department of Cellular Neuroscience, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany. ^[3] Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany; International Max Planck Research School for Translational Psychiatry (IMPRS-TP), 80804 Munich, Germany. ^[4] Department of Veterinary Resources, Weizmann Institute of Science, Rehovot 76100, Israel. ^[5] Bioinformatics Unit, Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot 76100, Israel. ^[6] Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, 80804 Munich, Germany. ^[7] Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany; Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden. Electronic address: jpablo.lopez@ki.se. ^[8] Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: alon.chen@weizmann.ac.il. ^[9]

关键词 ARS CMS CP: Neuroscience PVN acute restraint stress hypothalamus oligodendrocytes sex differences single-cell RNA-seq stress unpredictable chronic mild stress

医学主题词小鼠(Mice);男(雄)性(Male);女(雌)性(Female);动物(Animals);应激, 心理学(Stress, Psychological);性征(Sex Characteristics);下丘脑(Hypothalamus)

DOI 10.1016/j.celrep.2023.112874

PMID 37516966

发布时间 2023-09-07

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