Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy.

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第一作者： Mengwu,Pan

第一单位： Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.

作者： Mengwu,Pan ^[1] ; Valeria,Solozobova ^[1] ; Nane C,Kuznik ^[1] ; Nicole,Jung ^[2] ; Simone,Gräßle ^[2] ; Victor,Gourain ^[3] ; Yvonne M,Heneka ^[2] ; Christina A,Cramer von Clausbruch ^[1] ; Olaf,Fuhr ^[4] ; Ravi S N,Munuganti ^[5] ; Danilo,Maddalo ^[1] ; Christine,Blattner ^[1] ; Antje,Neeb ^[6] ; Adam,Sharp ^[7] ; Laura,Cato ^[8] ; Carsten,Weiss ^[1] ; Rinath M,Jeselsohn ^[8] ; Veronique,Orian-Rousseau ^[2] ; Stefan,Bräse ^[9] ; Andrew C B,Cato ^[1]

作者单位： Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany. ^[1] Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany. ^[2] Nantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France. ^[3] Institute of Nanotechnology and Karlsruhe Nano Micro Facility (KNMFi), Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany. ^[4] Vancouver Prostate Centre, Vancouver, British Columbia, Canada. ^[5] Institute of Cancer Research, London, United Kingdom. ^[6] Institute of Cancer Research, London, United Kingdom.;The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom. ^[7] Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.;Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts. ^[8] Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.;Institute of Organic Chemistry, Karlsruhe Institute of Technology, Karlsruhe, Germany. ^[9]

主题词女(雌)性(Female);人类(Humans);乳腺肿瘤(Breast Neoplasms);雌激素拮抗剂(Estrogen Antagonists);雌激素受体α(Estrogen Receptor alpha);雌激素类(Estrogens);受体, 雌激素(Receptors, Estrogen);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)

DOI 10.1158/2767-9764.CRC-23-0111

PMID 37520743

发布时间 2024-03-13

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Cancer research communications

2023年3卷7期

1378-1396页

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Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy.

Cancer research communications

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Cancer research communications

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Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy.

Cancer research communications

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Cancer research communications

相关期刊

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