Data-driven large-scale genomic analysis reveals an intricate phylogenetic and functional landscape in J-domain proteins.

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作者： Duccio,Malinverni ^[1] ; Stefano,Zamuner ^[2] ; Mathieu E,Rebeaud ^[2] ; Alessandro,Barducci ^[3] ; Nadinath B,Nillegoda ^[4] ; Paolo,De Los Rios ^[5]

作者单位： Department of Structural Biology and Center for Data Driven Discovery, St. Jude Children's Research Hospital, Memphis, TN 38105. ^[1] Institute of Physics, School of Basic Sciences, École Polytechnique Fédérale de Lausanne, CH-1015, Lausanne, Switzerland. ^[2] Centre de Biologie Structurale, Université de Montpellier, CNRS, INSERM, Montpellier, France. ^[3] Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC 3800, Australia. ^[4] Centre for Dementia and Brain Repair at the Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC 3800, Australia. ^[5] Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne, CH-1015, Lausanne, Switzerland. ^[6]

关键词 Hsp40 co-chaperones J-domain proteins artificial neural networks large-scale data analysis protein homeostasis

主题词人类(Humans);氨基酸序列(Amino Acid Sequence);基因组学(Genomics);HSP40热休克蛋白质类(HSP40 Heat-Shock Proteins);HSP70热休克蛋白质类(HSP70 Heat-Shock Proteins);分子伴侣(Molecular Chaperones);种系发生(Phylogeny)

DOI 10.1073/pnas.2218217120

PMID 37523524

发布时间 2024-02-01

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