The CAR-HEMATOTOX score as a prognostic model of toxicity and response in patients receiving BCMA-directed CAR-T for relapsed/refractory multiple myeloma.

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第一作者： Kai,Rejeski

第一单位： Department of Medicine III - Hematology/Oncology, LMU University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany. kai.rejeski@med.uni-muenchen.de.

作者： Kai,Rejeski ^[1] ; Doris K,Hansen ^[2] ; Radhika,Bansal ^[3] ; Pierre,Sesques ^[4] ; Sikander,Ailawadhi ^[5] ; Jennifer M,Logue ^[6] ; Eva,Bräunlein ^[7] ; David M,Cordas Dos Santos ^[8] ; Ciara L,Freeman ^[5] ; Melissa,Alsina ^[9] ; Sebastian,Theurich ^[10] ; Yucai,Wang ^[11] ; Angela M,Krackhardt ^[5] ; Frederick L,Locke ^[5] ; Emmanuel,Bachy ^[10] ; Michael D,Jain ^[11] ; Yi,Lin ^[6] ; Marion,Subklewe ^[11]

作者单位： Department of Medicine III - Hematology/Oncology, LMU University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany. kai.rejeski@med.uni-muenchen.de. ^[1] Laboratory for Translational Cancer Immunology, LMU Gene Center, Munich, Germany. kai.rejeski@med.uni-muenchen.de. ^[2] German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. kai.rejeski@med.uni-muenchen.de. ^[3] Bavarian Cancer Research Center (BZKF), Munich partner site, Munich, Germany. kai.rejeski@med.uni-muenchen.de. ^[4] Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, USA. ^[5] Division of Hematology, Mayo Clinic, Rochester, MN, USA. ^[6] Hospices Civils de Lyon, Université Claude Bernard Lyon 1, INSERM 1052, Pierre-Bénite, France. ^[7] Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USA. ^[8] IIIrd Medical Department, Klinikum rechts der Isar and Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany. ^[9] Department of Medicine III - Hematology/Oncology, LMU University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany. ^[10] German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. ^[11] Bavarian Cancer Research Center (BZKF), Munich partner site, Munich, Germany. ^[12] Department of Medicine I, Malteser Hospital St. Franziskus Hospital, Flensburg, Germany. ^[13] Laboratory for Translational Cancer Immunology, LMU Gene Center, Munich, Germany. ^[14]

关键词 BCMA CAR-T Chimeric antigen receptor Cytopenias Hematological toxicity Infections Multiple myeloma

主题词人类(Humans);多发性骨髓瘤(Multiple Myeloma);B细胞成熟抗原(B-Cell Maturation Antigen);预后(Prognosis);回顾性研究(Retrospective Studies);免疫疗法, 过继(Immunotherapy, Adoptive)

DOI 10.1186/s13045-023-01465-x

PMID 37525244

发布时间 2024-06-19

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准确一般字义偏差语意偏离译文作用小提交