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Targeting Alpha-Ketoglutarate Disruption Overcomes Immunoevasion and Improves PD-1 Blockade Immunotherapy in Renal Cell Carcinoma.

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作者: Le,Li [1] ; Xing,Zeng [2] ; Zheng,Chao [1] ; Jing,Luo [3] ; Wei,Guan [2] ; Qiang,Zhang [4] ; Yue,Ge [2] ; Yanan,Wang [2] ; Zezhong,Xiong [2] ; Sheng,Ma [2] ; Qiang,Zhou [2] ; Junbiao,Zhang [2] ; Jihua,Tian [2] ; David,Horne [5] ; Bertram,Yuh [5] ; Zhiquan,Hu [2] ; Gong-Hong,Wei [6] ; Baojun,Wang [7] ; Xu,Zhang [7] ; Peixiang,Lan [8] ; Zhihua,Wang [2]
作者单位: Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.;Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, 430030, China. [1] Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. [2] Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P.R. China. [3] Department of Medicine, Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. [4] Department of Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA. [5] Fudan University Shanghai Cancer Center & MOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, 200032, China. [6] Department of Urology, the Third Medical Center, Chinese PLA General Hospital, No.39 Yongding Road, Beijing, 100039, China. [7] Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, 430030, China. [8]
DOI 10.1002/advs.202301975
PMID 37526345
发布时间 2024-09-30
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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2023年10卷27期

e2301975页

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