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首页> The oncologist> A Phase I Dose-Escalation Study of LY3405105, a Covalent Inhibitor of Cyclin-Dependent Kinase 7, Administered to Patients With Advanced Solid Tumors.

A Phase I Dose-Escalation Study of LY3405105, a Covalent Inhibitor of Cyclin-Dependent Kinase 7, Administered to Patients With Advanced Solid Tumors.

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作者： Elena,Garralda ^[1] ; Alison M,Schram ^[2] ; Philippe L,Bedard ^[3] ; Gary K,Schwartz ^[4] ; Eunice,Yuen ^[5] ; Samuel C,McNeely ^[6] ; Silvia,Ribeiro ^[6] ; Jason,Cunningham ^[6] ; Yi,Wang ^[6] ; Arantxa,Urunuela ^[6] ; Xiaojian,Xu ^[6] ; Patricia,LoRusso ^[6]

作者单位： Department of Medical Oncology, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. ^[1] Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA. ^[2] Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. ^[3] Department of Medicine, University of Toronto, Toronto, Ontario, Canada. ^[4] Columbia University Vagelos School of Medicine, Herbert Irving Comprehensive Cancer Center, New York, NY, USA. ^[5] Eli Lilly and Company, Indianapolis, IN, USA. ^[6] Yale Cancer Center, New Haven, CT, USA. ^[7]

关键词 cyclin-dependent kinase 7 cyclin-dependent kinase inhibitor phase I solid tumors

主题词成年人(Adult);人类(Humans);虚弱(Asthenia);贝叶斯定理(Bayes Theorem);肿瘤(Neoplasms);蛋白激酶抑制剂(Protein Kinase Inhibitors);疲劳(Fatigue);细胞周期蛋白质依赖激酶类(Cyclin-Dependent Kinases);最大耐受剂量(Maximum Tolerated Dose);剂量效应关系, 药物(Dose-Response Relationship, Drug);抗肿瘤药(Antineoplastic Agents)

DOI 10.1093/oncolo/oyad215

PMID 37531083

发布时间 2024-03-12

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The oncologist

The oncologist

2024年29卷1期

e131-e140页

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