Synergistic efficacy of PI3Kδ inhibitor with anti-PD-1 mAbs in immune-humanized PDX model of endocrine resistance hormone receptor-positive advanced breast cancer.

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第一作者： Yingjue,Li

第一单位： Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, PR China.

作者： Yingjue,Li ^[1] ; Yiwen,Li ^[1] ; Yu,Yang ^[1] ; Yuwei,Deng ^[2] ; Xiangdong,Ni ^[3] ; Bochen,Zhao ^[4] ; Zhaoqi,Yan ^[5] ; Wen,He ^[1] ; Yixin,Li ^[6] ; Shuhui,Li ^[1] ; Linbo,Liu ^[1] ; Dan,Lu ^[1]

作者单位： Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, PR China. ^[1] Department of Oncology, Affiliated Oncology Hospital of Harbin Medical University, PR China. ^[2] Department of Oncology, Hegang People's Hospital, PR China. ^[3] Department of Oncology, General Hospital of Shenzhen University, PR China. ^[4] Department of Breast Surgery, The Second Affiliated Hospital of Harbin Medical University, PR China. ^[5] Department of Oncology, Second Affiliated Hospital of Medical College of Shantou University, PR China. ^[6]

关键词 Breast cancer (BC)Endocrine therapy resistance Humanized mice Immune checkpoint inhibitors PI3Kδ inhibitor Patient-derived xenograft

DOI 10.1016/j.heliyon.2023.e18498

PMID 37533997

发布时间 2023-08-04

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2023年9卷8期

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Synergistic efficacy of PI3Kδ inhibitor with anti-PD-1 mAbs in immune-humanized PDX model of endocrine resistance hormone receptor-positive advanced breast cancer.

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Synergistic efficacy of PI3Kδ inhibitor with anti-PD-1 mAbs in immune-humanized PDX model of endocrine resistance hormone receptor-positive advanced breast cancer.

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