Development and validation of derivatization-based LC-MS/MS method for quantification of short-chain fatty acids in human, rat, and mouse plasma.

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第一作者： Chiara,Vagaggini

第一单位： Department of Biotechnology, Chemistry, and Pharmacy (DBCF), University of Siena, 53100 Siena Italy. Electronic address: chiara.vagaggini@student.unisi.it.

作者： Chiara,Vagaggini ^[1] ; Annalaura,Brai ^[2] ; Denise,Bonente ^[3] ; Jessica,Lombardi ^[4] ; Federica,Poggialini ^[5] ; Claudia,Pasqualini ^[6] ; Virginia,Barone ^[7] ; Claudio,Nicoletti ^[8] ; Eugenio,Bertelli ^[9] ; Elena,Dreassi ^[10]

作者单位： Department of Biotechnology, Chemistry, and Pharmacy (DBCF), University of Siena, 53100 Siena Italy. Electronic address: chiara.vagaggini@student.unisi.it. ^[1] Department of Biotechnology, Chemistry, and Pharmacy (DBCF), University of Siena, 53100 Siena Italy. Electronic address: annalaura.brai@unisi.it. ^[2] Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy; Department of Life Sciences, University of Siena, 53100 Siena, Italy. Electronic address: denise.bonente@student.unisi.it. ^[3] Department of Biotechnology, Chemistry, and Pharmacy (DBCF), University of Siena, 53100 Siena Italy. Electronic address: jessica_lombardi@virgilio.it. ^[4] Department of Biotechnology, Chemistry, and Pharmacy (DBCF), University of Siena, 53100 Siena Italy. Electronic address: federic.poggialini@unisi.it. ^[5] Department of Biotechnology, Chemistry, and Pharmacy (DBCF), University of Siena, 53100 Siena Italy. Electronic address: pasqualini5@student.unisi.it. ^[6] Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy. Electronic address: virginia.barone@unisi.it. ^[7] Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy; The Quadram Institute Bioscience, Norwich, United Kingdom. Electronic address: claudio.nicoletti@unisi.it. ^[8] Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy. Electronic address: eugenio.bertelli@unisi.it. ^[9] Department of Biotechnology, Chemistry, and Pharmacy (DBCF), University of Siena, 53100 Siena Italy. Electronic address: elena.dreassi@unisi.it. ^[10]

关键词 Gut-brain axis Human, rat, and mouse plasma LC-MS/MS Microbiota O-benzylhydroxylamine Quantification Short-chain fatty acids