Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold.

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第一作者： Katerina,Novotna

第一单位： Johns Hopkins Drug Discovery, United States; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic V.v.i., Prague, 166 00, Czech Republic; Department of Organic Chemistry, Charles University, Prague, 128 00, Czech Republic.

作者： Katerina,Novotna ^[1] ; Ajit G,Thomas ^[2] ; Ondrej,Stepanek ^[3] ; Brennan,Murphy ^[3] ; Niyada,Hin ^[2] ; Jan,Skacel ^[2] ; Louis,Mueller ^[3] ; Lukas,Tenora ^[4] ; Arindom,Pal ^[3] ; Jesse,Alt ^[2] ; Ying,Wu ^[2] ; James,Paule ^[2] ; Rana,Rais ^[5] ; Barbara S,Slusher ^[5] ; Takashi,Tsukamoto ^[6]

作者单位： Johns Hopkins Drug Discovery, United States; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic V.v.i., Prague, 166 00, Czech Republic; Department of Organic Chemistry, Charles University, Prague, 128 00, Czech Republic. ^[1] Johns Hopkins Drug Discovery, United States. ^[2] Johns Hopkins Drug Discovery, United States; Department of Neurology, United States. ^[3] Johns Hopkins Drug Discovery, United States; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic V.v.i., Prague, 166 00, Czech Republic. ^[4] Johns Hopkins Drug Discovery, United States; Department of Neurology, United States; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21205, United States. ^[5] Johns Hopkins Drug Discovery, United States; Department of Neurology, United States; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21205, United States. Electronic address: ttsukamoto@jhmi.edu. ^[6]

关键词 Ceramide Neutral sphingomyelinase 2 Phosphodiesterase Pyrazolo[1,5-a]pyrimidin-3-amine Sphingomyelin

主题词人类(Humans);鞘磷脂磷酸二酯酶(Sphingomyelin Phosphodiesterase);胺类(Amines);嘧啶类(Pyrimidines);神经酰胺类(Ceramides)

DOI 10.1016/j.ejmech.2023.115674

PMID 37536209

发布时间 2024-11-06

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