Thrombocytopenia is associated with a dysregulated host response in severe COVID-19.

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第一作者： Brent,Appelman

第一单位： Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands. Electronic address: b.appelman@amsterdamumc.nl.

作者： Brent,Appelman ^[1] ; Erik H A,Michels ^[2] ; Justin,de Brabander ^[2] ; Hessel,Peters-Sengers ^[3] ; Rombout B E,van Amstel ^[4] ; Sophie M,Noordzij ^[2] ; Augustijn M,Klarenbeek ^[2] ; Christine C A,van Linge ^[2] ; Osoul,Chouchane ^[2] ; Alex R,Schuurman ^[2] ; Tom D Y,Reijnders ^[2] ; Renée A,Douma ^[5] ; Lieuwe D J,Bos ^[4] ; Amsterdam UMC COVID-19 Biobank study group ^[6] ; CovidPredict study group ^[6] ; W Joost,Wiersinga ; Tom,van der Poll

作者单位： Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands. Electronic address: b.appelman@amsterdamumc.nl. ^[1] Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands. ^[2] Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Boelelaan 1117, Amsterdam, the Netherlands. ^[3] Amsterdam UMC location University of Amsterdam, Department of Intensive Care Medicine, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands. ^[4] Flevo Hospital, Department of Internal Medicine, Almere, the Netherlands. ^[5] Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands; Amsterdam UMC location University of Amsterdam, Division of Infectious Diseases, Department of Medicine, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands. ^[6]

关键词 COVID-19 Host immune response Mortality Platelets Thrombocytopenia

主题词人类(Humans);血小板减少(Thrombocytopenia);贫血(Anemia);炎症(Inflammation);细胞因子类(Cytokines)

DOI 10.1016/j.thromres.2023.07.008

PMID 37541167

发布时间 2023-09-26

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