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Report on 4 cases with decreased recovery due to neutralizing antibodies specific for PEGylated recombinant factor VIII.

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第一作者： Andreas,Hillarp

第一单位： Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway; Department of Translational Medicine, Lund University, Lund, Sweden.

作者： Andreas,Hillarp ^[1] ; Pål A,Holme ^[2] ; Erik P,Wåland ^[3] ; Marie S,Le ^[3] ; Carola E,Henriksson ^[4] ; Geir E,Tjønnfjord ^[5] ; Ragnhild J,Måseide ^[6]

作者单位： Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway; Department of Translational Medicine, Lund University, Lund, Sweden. ^[1] Department of Haematology, Oslo University Hospital, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. ^[2] Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway. ^[3] Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. ^[4] Department of Haematology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. ^[5] Department of Haematology, Oslo University Hospital, Oslo, Norway. Electronic address: ragmas@ous-hf.no. ^[6]

关键词 FVIII recovery PEGylated recombinant FVIII products extended half-life FVIII products hemophilia A neutralizing anti-PEG antibodies