Silibinin exerts neuroprotective effects against cerebral hypoxia/reoxygenation injury by activating the GAS6/Axl pathway.

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第一作者： Weiping,Li

第一单位： Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences and Medicine, Northwest University, 229 Taibai North Road, Xi'an 710069, China; Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No.3 Hospital, Faculty of Life Sciences and Medicine, Northwest University, 10 Fengcheng Three Road, Xi'an 710021, China.

作者： Weiping,Li ^[1] ; Zhe,Zhang ^[2] ; Jiawen,Li ^[1] ; Jun,Mu ^[1] ; Meng,Sun ^[3] ; Xue,Wu ^[1] ; Xiaochen,Niu ^[1] ; Yang,Yang ^[1] ; Huanle,Yan ^[1] ; Xiaoling,Xu ^[1] ; Chengxu,Xue ^[1] ; Lu,Qian ^[4] ; Ye,Tian ^[5]

作者单位： Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences and Medicine, Northwest University, 229 Taibai North Road, Xi'an 710069, China; Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No.3 Hospital, Faculty of Life Sciences and Medicine, Northwest University, 10 Fengcheng Three Road, Xi'an 710021, China. ^[1] Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences and Medicine, Northwest University, 229 Taibai North Road, Xi'an 710069, China. ^[2] Department of Cardiology, The First Hospital of Shanxi Medical University, 85 Jiefang South Road, Taiyuan 030001, China. ^[3] Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences and Medicine, Northwest University, 229 Taibai North Road, Xi'an 710069, China; Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No.3 Hospital, Faculty of Life Sciences and Medicine, Northwest University, 10 Fengcheng Three Road, Xi'an 710021, China. Electronic address: luqiannorthwest@163.com. ^[4] Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences and Medicine, Northwest University, 229 Taibai North Road, Xi'an 710069, China; Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No.3 Hospital, Faculty of Life Sciences and Medicine, Northwest University, 10 Fengcheng Three Road, Xi'an 710021, China. Electronic address: yetiannorthwest@163.com. ^[5]

关键词 Apoptosis Hypoxia/reoxygenation Mitochondria dysfunction Oxidative stress Silibinin

主题词人类(Humans);神经保护药(Neuroprotective Agents);缺氧, 脑(Hypoxia, Brain);细胞凋亡(Apoptosis)

DOI 10.1016/j.tox.2023.153598

PMID 37544575

发布时间 2023-09-08

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