The role of PERK-eIF2α-ATF4-CHOP pathway in sevoflurane induced neuroapoptosis and cognitive dysfunction in aged mice.

导出 LinkOut

翻译打印收藏纠错

作者： Yuhao,Wang ^[1] ; Di,Wu ^[2] ; Danni,Li ^[3] ; Xueer,Zhou ^[1] ; Dan,Fan ^[4] ; Jian,Pan ^[5]

作者单位： State Key Laboratory of Oral Disease & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, PR China; Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, PR China. ^[1] State Key Laboratory of Oral Disease & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, PR China. ^[2] Department of Anesthesiology, Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, Chengdu 610072, PR China; School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, PR China. ^[3] Department of Anesthesiology, Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, Chengdu 610072, PR China; School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, PR China. Electronic address: fandan1976@163.com. ^[4] State Key Laboratory of Oral Disease & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, PR China; Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, PR China. Electronic address: jianpancn@scu.edu.cn. ^[5]

关键词 Apoptosis Cognitive impairment ER stress General anesthetic hippocampus