A Novel Interaction between MFN2/Marf and MARK4/PAR-1 Is Implicated in Synaptic Defects and Mitochondrial Dysfunction.

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作者： Yeongmi,Cheon ^[1] ; Sunggyu,Yoon ^[2] ; Jae-Hyuk,Lee ^[3] ; Kiyoung,Kim ^[1] ; Hyung-Jun,Kim ^[4] ; Sung Wook,Hong ^[1] ; Ye-Rang,Yun ^[5] ; Jiwon,Shim ^[6] ; Sung-Hak,Kim ^[7] ; Bingwei,Lu ^[7] ; Mihye,Lee ^[4] ; Seongsoo,Lee ^[2]

作者单位： Gwangju Center, Korea Basic Science Institute, Gwangju 61751, Korea. ^[1] Laboratory of Molecular Biochemistry, Chonnam National University, Gwangju 61186, Korea. ^[2] Department of Microbiology and Molecular Biology, Chungnam National University, Daejeon 34134, Korea. ^[3] Department of Life Science, College of Natural Science, Hanyang University, Seoul 04763, Korea. ^[4] Department of Medical Science, Soonchunhyang University, Asan 31538, Korea. ^[5] Dementia Research Group, Korea Brain Research Institute, Daegu 41068, Korea. ^[6] Kimchi Functionality Research Group, World Institute of Kimchi, Gwangju 61755, Korea. ^[7] Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 soolee@kbsi.re.kr bingwei@stanford.edu mihyelee@sch.ac.kr. ^[8] Soonchunhyang Institute of Medi-Bio Science, Soonchunhyang University, Cheonan 31151, Korea soolee@kbsi.re.kr bingwei@stanford.edu mihyelee@sch.ac.kr. ^[9] Gwangju Center, Korea Basic Science Institute, Gwangju 61751, Korea soolee@kbsi.re.kr bingwei@stanford.edu mihyelee@sch.ac.kr. ^[10]

关键词 Drosophila melanogaster MARK4/PAR-1 MFN2/Marf mitochondrial dynamics neurodegenerative disease

主题词动物(Animals);人类(Humans);果蝇属(Drosophila);果蝇蛋白质类(Drosophila Proteins);GTP磷酸水解酶类(GTP Phosphohydrolases);哺乳动物(Mammals);微管(Microtubules);线粒体(Mitochondria);线粒体蛋白质类(Mitochondrial Proteins);突触(Synapses)

DOI 10.1523/ENEURO.0409-22.2023

PMID 37550059

发布时间 2023-08-25

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2023年10卷8期

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A Novel Interaction between MFN2/Marf and MARK4/PAR-1 Is Implicated in Synaptic Defects and Mitochondrial Dysfunction.

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A Novel Interaction between MFN2/Marf and MARK4/PAR-1 Is Implicated in Synaptic Defects and Mitochondrial Dysfunction.

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