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Precision RNAi using synthetic shRNAmir target sites.

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第一作者： Thomas,Hoffmann

第一单位： Research Institute of Molecular Pathology (IMP), Campus-Vienna-Biocenter 1, Vienna, Austria.;Vienna BioCenter PhD Program, Doctoral School of the University at Vienna and Medical University of Vienna, Vienna BioCenter (VBC), Vienna, Austria.

作者： Thomas,Hoffmann ^[1] ; Alexandra,Hörmann ^[2] ; Maja,Corcokovic ^[2] ; Jakub,Zmajkovic ^[3] ; Matthias,Hinterndorfer ^[3] ; Jasko,Salkanovic ^[2] ; Fiona,Spreitzer ^[2] ; Anna,Köferle ^[2] ; Katrin,Gitschtaler ^[2] ; Alexandra,Popa ^[2] ; Sarah,Oberndorfer ^[2] ; Florian,Andersch ^[3] ; Markus,Schaefer ^[3] ; Michaela,Fellner ^[3] ; Nicole,Budano ^[2] ; Jan G,Ruppert ^[2] ; Paolo,Chetta ^[2] ; Melanie,Wurm ^[2] ; Johannes,Zuber ^[4] ; Ralph A,Neumüller ^[2]

作者单位： Research Institute of Molecular Pathology (IMP), Campus-Vienna-Biocenter 1, Vienna, Austria.;Vienna BioCenter PhD Program, Doctoral School of the University at Vienna and Medical University of Vienna, Vienna BioCenter (VBC), Vienna, Austria. ^[1] Boehringer Ingelheim RCV GmbH & Co KG, Doktor-Boehringer-Gasse, Vienna, Austria. ^[2] Research Institute of Molecular Pathology (IMP), Campus-Vienna-Biocenter 1, Vienna, Austria. ^[3] Research Institute of Molecular Pathology (IMP), Campus-Vienna-Biocenter 1, Vienna, Austria.;Medical University of Vienna, Vienna BioCenter, Vienna, Austria. ^[4]

关键词 EGFR KRAS RNAi cancer cancer biology human loss-of-function mouse target validation

医学主题词 RNA干扰(RNA Interference);RNA, 小分子干扰(RNA, Small Interfering)

DOI 10.7554/eLife.84792

PMID 37552050

发布时间 2023-08-10

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准确一般字义偏差语意偏离译文作用小提交