Discovery, SAR Study of GST Inhibitors from a Novel Quinazolin-4(1<i>H</i>)-one Focused DNA-Encoded Library.

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第一作者： Xin,Wen

第一单位： State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai 201203, P. R. China.;University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.

作者： Xin,Wen ^[1] ; Minmin,Zhang ^[1] ; Zhiqiang,Duan ^[2] ; Yanrui,Suo ^[1] ; Weiwei,Lu ^[2] ; Rui,Jin ^[2] ; Baiyang,Mu ^[2] ; Kaige,Li ^[2] ; Xu,Zhang ^[1] ; Linghua,Meng ^[1] ; Yu,Hong ^[1] ; Xingyu,Wang ^[1] ; Hangchen,Hu ^[2] ; Jian,Zhu ^[3] ; Weixiao,Song ^[3] ; Aijun,Shen ^[4] ; Xiaojie,Lu ^[1]

作者单位： State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai 201203, P. R. China.;University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China. ^[1] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai 201203, P. R. China. ^[2] Protein Crystallography Platform, WuXi AppTec (Suzhou) Co., Ltd., 1318 Wuzhong Avenue, Wuzhong District, Suzhou 215104, China. ^[3] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai 201203, P. R. China.;University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.;Lingang Laboratory, Shanghai 200031, China. ^[4]

主题词酶抑制剂(Enzyme Inhibitors);谷胱甘肽转移酶(Glutathione Transferase);构效关系(Structure-Activity Relationship);喹唑啉酮类(Quinazolinones)

DOI 10.1021/acs.jmedchem.2c02129

PMID 37552553

发布时间 2024-08-09

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