Anti-PD-L1 antibodies promote cellular proliferation by activating the PD-L1-AXL signal relay in liver cancer cells.

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作者： Toshimitsu,Tanaka ^[1] ; Hironori,Koga ^[2] ; Hiroyuki,Suzuki ^[1] ; Hideki,Iwamoto ^[1] ; Takahiko,Sakaue ^[1] ; Atsutaka,Masuda ^[1] ; Toru,Nakamura ^[1] ; Jun,Akiba ^[3] ; Hirohisa,Yano ^[4] ; Takuji,Torimura ^[1] ; Takumi,Kawaguchi ^[5]

作者单位： Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.;Liver Cancer Research Division, Research Center for Innovative Cancer Therapy, Kurume University, 67 Asahi-machi, Kurume, 830-0011, Japan. ^[1] Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan. hirokoga@med.kurume-u.ac.jp.;Liver Cancer Research Division, Research Center for Innovative Cancer Therapy, Kurume University, 67 Asahi-machi, Kurume, 830-0011, Japan. hirokoga@med.kurume-u.ac.jp. ^[2] Department of Diagnostic Pathology, Kurume University Hospital, 67 Asahi-machi, Kurume, 830-0011, Japan. ^[3] Department of Pathology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan. ^[4] Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan. ^[5]

关键词 Glycosylation Hyperprogressive disease Immune checkpoint inhibitor Interprotein interaction Tumor microenvironment