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Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts.

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作者单位: Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.;Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.;COVID-19 International Research Team, Medford, MA 02155, USA . [1] Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.;COVID-19 International Research Team, Medford, MA 02155, USA . [2] Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.;Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.;COVID-19 International Research Team, Medford, MA 02155, USA .;Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, South Korea. [3] Icahn School of Medicine at Mount Sinai, New York, NY 10023, USA. [4] Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.;Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. [5] COVID-19 International Research Team, Medford, MA 02155, USA .;Rocky Mountain Laboratory, National Institute of Allergy and Infectious Disease, NIH, Hamilton, MT 59840, USA. [6] University of Nottingham, Nottingham, UK. [7] COVID-19 International Research Team, Medford, MA 02155, USA .;University of Chicago, Chicago, IL 60615, USA.;Clever Research Lab, Springfield, IL 62704, USA. [8] COVID-19 International Research Team, Medford, MA 02155, USA .;Logyx, LLC, Mountain View, CA 94043, USA.;NASA Ames Research Center, Moffett Field, CA 94035, USA. [9] COVID-19 International Research Team, Medford, MA 02155, USA .;Weill Cornell Medicine, New York, NY 10065, USA. [10] Weill Cornell Medicine, New York, NY 10065, USA. [11] COVID-19 International Research Team, Medford, MA 02155, USA .;Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA. [12] COVID-19 International Research Team, Medford, MA 02155, USA .;University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. [13] COVID-19 International Research Team, Medford, MA 02155, USA .;University of Texas Medical Branch, Galveston, TX 77555, USA. [14] COVID-19 International Research Team, Medford, MA 02155, USA .;Morehouse School of Medicine, Atlanta, GA 30310, USA. [15] DKAbzu ApS, Copenhagen 2150, Denmark. [16] COVID-19 International Research Team, Medford, MA 02155, USA .;Facultad de Ingeniería, Universidad Nacional de Asunción, San Lorenzo, Central, Paraguay. [17] COVID-19 International Research Team, Medford, MA 02155, USA .;Faculdade de Medicina, Universidade de Lisboa, Instituto de Medicina Molecular João Lobo Antunes, 1649-028 Lisboa, Portugal. [18] College of Physicians and Surgeons, Columbia University, New York, NY 19103, USA. [19] COVID-19 International Research Team, Medford, MA 02155, USA .;Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA. [20] COVID-19 International Research Team, Medford, MA 02155, USA .;Iowa State University, Ames, IA 50011, USA. [21] Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.;Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.;COVID-19 International Research Team, Medford, MA 02155, USA .;Iowa State University, Ames, IA 50011, USA. [22] University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. [23] COVID-19 International Research Team, Medford, MA 02155, USA .;Johns Hopkins School of Medicine, Baltimore, MD 21287, USA. [24] COVID-19 International Research Team, Medford, MA 02155, USA .;University of Campinas, Campinas, SP, Brazil. [25] COVID-19 International Research Team, Medford, MA 02155, USA .;Weill Cornell Medicine, New York, NY 10065, USA.;New York Genome Center, New York, NY 10013, USA. [26] COVID-19 International Research Team, Medford, MA 02155, USA .;University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. [27] COVID-19 International Research Team, Medford, MA 02155, USA .;Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA. [28] Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.;Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.;COVID-19 International Research Team, Medford, MA 02155, USA .;Division of Human Genetics, Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA. [29]
DOI 10.1126/scitranslmed.abq1533
PMID 37556555
发布时间 2024-12-08
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