Integrative splicing-quantitative-trait-locus analysis reveals risk loci for non-small-cell lung cancer.

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作者： Yuzhuo,Wang ^[1] ; Yue,Ding ^[2] ; Su,Liu ^[2] ; Cheng,Wang ^[3] ; Erbao,Zhang ^[2] ; Congcong,Chen ^[2] ; Meng,Zhu ^[2] ; Jing,Zhang ^[2] ; Chen,Zhu ^[4] ; Mengmeng,Ji ^[2] ; Juncheng,Dai ^[2] ; Guangfu,Jin ^[2] ; Zhibin,Hu ^[2] ; Hongbing,Shen ^[5] ; Hongxia,Ma ^[6]

作者单位： Department of Medical Informatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China. ^[1] Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China. ^[2] Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Department of Bioinformatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, Jiangsu 211166, China. ^[3] Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Department of Cancer Prevention, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang 310022, China. ^[4] Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Research Units of Cohort Study on Cardiovascular Diseases and Cancers, Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address: hbshen@njmu.edu.cn. ^[5] Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China. Electronic address: hongxiama@njmu.edu.cn. ^[6]

关键词 FARP1 exon 20 skipping non-small-cell lung cancer risk loci splice-transcriptome-wide association study splicing quantitative trait locus

主题词人类(Humans);数量性状基因座位(Quantitative Trait Loci);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);全基因组关联研究(Genome-Wide Association Study);肺肿瘤(Lung Neoplasms);选择性剪接(Alternative Splicing);多态性, 单核苷酸(Polymorphism, Single Nucleotide)

DOI 10.1016/j.ajhg.2023.07.008

PMID 37562399

发布时间 2024-03-08

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