HCS-Splice: A High-Content Screening Method to Advance the Discovery of RNA Splicing-Modulating Therapeutics.

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作者： Giuseppina,Covello ^[1] ; Kavitha,Siva ^[1] ; Valentina,Adami ^[2] ; Michela Alessandra,Denti ^[1]

作者单位： RNA Biology and Biotechnology Laboratory, Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, 38123 Trento, Italy. ^[1] High Throughput Screening and Validation Core Facility (HTS), Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, 38123 Trento, Italy. ^[2]

关键词 FTDP-17 MAPT alternative splicing drug discovery exon-skipping high content screening nucleic acids therapeutics siRNA two-colour (GFP/RFP) fluorescent reporter

主题词人类(Humans);RNA剪接(RNA Splicing);选择性剪接(Alternative Splicing);突变(Mutation)

DOI 10.3390/cells12151959

PMID 37566038

发布时间 2023-08-15

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2023年12卷15期

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HCS-Splice: A High-Content Screening Method to Advance the Discovery of RNA Splicing-Modulating Therapeutics.

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HCS-Splice: A High-Content Screening Method to Advance the Discovery of RNA Splicing-Modulating Therapeutics.

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