ZNF143 inhibits hepatocyte mitophagy and promotes non-alcoholic fatty liver disease by targeting increased lncRNA NEAT1 expression to activate ROCK2 pathway.

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作者： Yujie,Dong ^[1] ; Minjie,Hu ^[2] ; Kewei,Tan ^[3] ; Rongjuan,Dai ^[4]

作者单位： The First Affiliated Hospital, Department of Ultrasound Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China. ^[1] The First Affiliated Hospital, Department of Cardiothoracic Surgery, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China. ^[2] The No.922 Hospital of the People Liberation Army Joint Logistics Support Force, Department of the Laboratory and Blood Transfusion, Hengyang, Hunan 421002, China. ^[3] The First Affiliated Hospital, Department of Infectious Diseases, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China. ^[4]

关键词 NAFLD ROCK2 SND1 ZNF143 lncRNA NEAT1 mitophagy

主题词动物(Animals);小鼠(Mice);DNA甲基化(DNA Methylation);肝细胞(Hepatocytes);肝(Liver);微RNAs(MicroRNAs);反式激活因子类(Trans-Activators)

DOI 10.1080/15592294.2023.2239592

PMID 37566742

发布时间 2024-04-25

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