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首页> International immunopharmacology> Restoration of miR-328a-5p function curtails hypoxic pulmonary hypertension through a mechanism involving PIN1/GSK3β/β-catenin axis.

Restoration of miR-328a-5p function curtails hypoxic pulmonary hypertension through a mechanism involving PIN1/GSK3β/β-catenin axis.

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作者： Jieqing,Yuan ^[1] ; Shanshan,Li ^[1] ; Yu,Han ^[1] ; Fujun,Li ^[2] ; Hai,Shi ^[1] ; Weitao,Shi ^[3] ; Wenjie,Cui ^[4]

作者单位： Department of Respiratory and Critical Care Medicine, The First People's Hospital of Xuzhou, the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou 221100, PR China. ^[1] Department of Emergency Medicine, The First People's Hospital of Xuzhou, the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou 221100, PR China. ^[2] Department of Critical Care Medicine, The First People's Hospital of Xuzhou, the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou 221100, PR China. ^[3] Department of Respiratory and Critical Care Medicine, The First People's Hospital of Xuzhou, the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou 221100, PR China. Electronic address: hxcwj329@163.com. ^[4]

关键词 GSK3β/β-catenin signaling pathway Hypoxia-induced pulmonary hypertension PIN1 Pulmonary artery smooth muscle cells Vascular inflammatory response miR-328a-5p

主题词动物(Animals);大鼠(Rats);β连环素(beta Catenin);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);高血压, 肺性(Hypertension, Pulmonary);微RNAs(MicroRNAs);肌细胞, 平滑肌(Myocytes, Smooth Muscle);肺动脉(Pulmonary Artery);大鼠, Sprague-Dawley(Rats, Sprague-Dawley)

DOI 10.1016/j.intimp.2023.110599

PMID 37567011

发布时间 2023-09-23

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International immunopharmacology

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