Eculizumab suppresses zymosan-induced release of inflammatory cytokines IL-1α, IL-1β, IFN-γ and IL-2 in autologous serum-substituted PBMC cultures: Relevance to cytokine storm in Covid-19.

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作者： Tamás,Bakos ^[1] ; Gergely T,Kozma ^[2] ; János,Szebeni ^[3] ; Gábor,Szénási ^[4]

作者单位： Institute of Translational Medicine, Semmelweis University, Budapest, Hungary. ^[1] SeroScience LTD., Budapest, Hungary. ^[2] SeroScience LTD., Budapest, Hungary; Nanomedicine Research and Education Center, Department of Translational Medicine, Semmelweis University, Budapest 1089, Hungary; Department of Nanobiotechnology and Regenerative Medicine, Faculty of Health Sciences, Miskolc University, Miskolc 2880, Hungary; School of Chemical Engineering and Translational Nanobioscience Research Center, Sungkyunkwan University, Suwon 16419, the Republic of Korea. ^[3] Institute of Translational Medicine, Semmelweis University, Budapest, Hungary. Electronic address: szenasi.gabor@med.semmelweis-univ.hu. ^[4]

关键词 Anaphylatoxin Complement activation Complement inhibitor/antagonist Cytokine storm PBMC

主题词人类(Humans);细胞因子类(Cytokines);白细胞介素2(Interleukin-2);酵母多糖(Zymosan);白细胞, 单核(Leukocytes, Mononuclear);白细胞介素8(Interleukin-8);干扰素γ(Interferon-gamma)

DOI 10.1016/j.biopha.2023.115294

PMID 37567071

发布时间 2023-09-18

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