1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding.

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作者： Rawia,Hamid ^[1] ; Sebastian,Adam ^[2] ; Antoine,Lacour ^[2] ; Leticia,Monjas ^[3] ; Jesko,Köhnke ^[4] ; Anna K H,Hirsch ^[5]

作者单位： Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany; Department of Pharmacy, Saarland University, Saarbrücken, Germany. ^[1] Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany. ^[2] Stratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands. ^[3] Institute of Food Chemistry, Leibniz University Hannover, Hannover, Germany; School of Chemistry, University of Glasgow, Glasgow, UK. ^[4] Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany; Department of Pharmacy, Saarland University, Saarbrücken, Germany. Electronic address: anna.hirsch@helmholtz-hips.de. ^[5]

关键词 1-deoxy-D-xylulose 5-phosphate synthase DXPS Klebsiella pneumonia Pseudomonas aeruginosa X-ray crystallography conformational changes