首页> Immunity> CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma.

CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma.

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第一作者： Dan,Chen

第一单位： NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

作者： Dan,Chen ^[1] ; Siva Karthik,Varanasi ^[1] ; Toshiro,Hara ^[2] ; Kacie,Traina ^[1] ; Ming,Sun ^[1] ; Bryan,McDonald ^[3] ; Yagmur,Farsakoglu ^[4] ; Josh,Clanton ^[1] ; Shihao,Xu ^[1] ; Lizmarie,Garcia-Rivera ^[3] ; Thomas H,Mann ^[1] ; Victor,Du ^[1] ; H Kay,Chung ^[1] ; Ziyan,Xu ^[5] ; Victoria,Tripple ^[1] ; Eduardo,Casillas ^[1] ; Shixin,Ma ^[1] ; Carolyn,O'Connor ^[6] ; Qiyuan,Yang ^[1] ; Ye,Zheng ^[1] ; Tony,Hunter ^[7] ; Greg,Lemke ^[8] ; Susan M,Kaech ^[9]

作者单位： NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. ^[1] Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. ^[2] NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA 92093, USA. ^[3] NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Department of Biomedicine, University of Basel, Basel 4058, Switzerland. ^[4] NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; School of Biological Sciences, University of California, San Diego, La Jolla, CA 92037, USA. ^[5] Flow Cytometry Core Facility, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. ^[6] Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. ^[7] Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. ^[8] NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: skaech@salk.edu. ^[9]

关键词 AXL CD4(+) T?cell CTLA-4 MER MHC-II glioblastoma immunotherapy microglia