A least-squares-fitting procedure for an efficient preclinical ranking of passive transport across the blood-brain barrier endothelium.

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作者： Christian,Jorgensen ^[1] ; Evan P,Troendle ^[2] ; Jakob P,Ulmschneider ^[3] ; Peter C,Searson ^[4] ; Martin B,Ulmschneider ^[5]

作者单位： Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA. Cjorgen4@jhu.edu. ^[1] Department of Chemistry, Aarhus University, Langelandsgade 140, 8000, Aarhus C, Denmark. Cjorgen4@jhu.edu. ^[2] Department of Chemistry, King's College, London, UK. ^[3] School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China. ^[4] Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA. ^[5] Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA. ^[6]

关键词 Blood–brain barrier Brain permeability CNS penetration Kinetics Molecular dynamics Transport properties

主题词人类(Humans);血脑屏障(Blood-Brain Barrier);生物转运(Biological Transport);通透性(Permeability);计算机模拟(Computer Simulation);内皮(Endothelium)

DOI 10.1007/s10822-023-00525-1

PMID 37573260

发布时间 2023-09-22

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准确一般字义偏差语意偏离译文作用小提交