Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers.

导出 LinkOut

翻译打印收藏纠错

第一作者： Laura,Braconi

第一单位： Department of Neuroscience, Psychology, Drug Research and Child Health - Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Italy.

作者： Laura,Braconi ^[1] ; Silvia,Dei ^[2] ; Marialessandra,Contino ^[3] ; Chiara,Riganti ^[4] ; Gianluca,Bartolucci ^[1] ; Dina,Manetti ^[1] ; Maria Novella,Romanelli ^[1] ; Maria Grazia,Perrone ^[3] ; Nicola Antonio,Colabufo ^[3] ; Stefano,Guglielmo ^[5] ; Elisabetta,Teodori ^[1]

作者单位： Department of Neuroscience, Psychology, Drug Research and Child Health - Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Italy. ^[1] Department of Neuroscience, Psychology, Drug Research and Child Health - Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Italy. Electronic address: silvia.dei@unifi.it. ^[2] Department of Pharmacy - Drug Sciences, University of Bari "A. Moro", via Orabona 4, 70125, Bari, Italy. ^[3] Department of Oncology, University of Turin, Via Santena 5/bis, 10126, Torino, Italy. ^[4] Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125, Torino, Italy. ^[5]

关键词 ABC transporter modulators MDR reversers Multidrug resistance Oxadiazole P-glycoprotein Tetrazole

主题词抗肿瘤药(Antineoplastic Agents);抗药性, 肿瘤(Drug Resistance, Neoplasm);构效关系(Structure-Activity Relationship);肿瘤蛋白质类(Neoplasm Proteins);抗药性, 多药(Drug Resistance, Multiple);四唑类(Tetrazoles);酰胺类(Amides)

DOI 10.1016/j.ejmech.2023.115716

PMID 37573829

发布时间 2023-08-22

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交