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Building an optimal predictive model for imputing tissue-specific gene expression by combining genotype and whole-blood transcriptome data.

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第一作者： Sunwoo,Jung

第一单位： Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Republic of Korea.

作者： Sunwoo,Jung ^[1] ; Cue Hyunkyu,Lee ^[2] ; Jae Hoon,Sul ^[3] ; Buhm,Han ^[4]

作者单位： Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Republic of Korea. ^[1] Department of Biostatistics, Columbia University, New York, NY, USA. ^[2] Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. ^[3] Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Republic of Korea.;Department of Biomedical Sciences, BK21 Plus Biomedical Science Project, Seoul National University College of Medicine, Seoul, Republic of Korea. ^[4]

关键词 GTEx TWAS Transcriptome-wide association studies eQTLs expression quantitative trait loci regularized linear regression transcriptome imputation whole blood expression

医学主题词人类(Humans);表型(Phenotype);全基因组关联研究(Genome-Wide Association Study);数量性状基因座位(Quantitative Trait Loci);多态性, 单核苷酸(Polymorphism, Single Nucleotide);基因型(Genotype)

DOI 10.1016/j.xhgg.2023.100223

PMID 37576186

发布时间 2023-08-17

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