Moderate mechanical strain and exercise reduce inflammation and excessive autophagy in osteoarthritis by downregulating mitofusin 2.

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作者： Xiaofeng,Deng ^[1] ; Haoran,Xu ^[2] ; Chunran,Pan ^[3] ; Xiaoxia,Hao ^[4] ; Jiawei,Liu ^[5] ; Xingru,Shang ^[6] ; Ruimin,Chi ^[7] ; Wenjie,Hou ^[8] ; Tao,Xu ^[9]

作者单位： Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: m202076125@hust.edu.cn. ^[1] Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: d202081999@hust.edu.cn. ^[2] Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: m202176105@hust.edu.cn. ^[3] Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: xiaoxiahao@hust.edu.cn. ^[4] Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: d202081967@hust.edu.cn. ^[5] Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: d202182027@hust.edu.cn. ^[6] Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: d202282094@hust.edu.cn. ^[7] Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: m202276333@hust.edu.cn. ^[8] Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: xutao@tjh.tjmu.edu.cn. ^[9]

关键词 Autophagy Exercise Inflammation Mechanical strain Mitofusin 2 Osteoarthritis