Deep Learning for Detecting BRCA Mutations in High-Grade Ovarian Cancer Based on an Innovative Tumor Segmentation Method From Whole Slide Images.

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第一作者： Raphaël,Bourgade

第一单位： Department of Pathology, University Hospital of Nantes, Nantes, France. Electronic address: raphael.bourgade@gmail.com.

作者： Raphaël,Bourgade ^[1] ; Noémie,Rabilloud ^[2] ; Tanguy,Perennec ^[3] ; Thierry,Pécot ^[4] ; Céline,Garrec ^[5] ; Alexis F,Guédon ^[6] ; Capucine,Delnatte ^[5] ; Stéphane,Bézieau ^[5] ; Alexandra,Lespagnol ^[7] ; Marie,de Tayrac ^[7] ; Sébastien,Henno ^[8] ; Christine,Sagan ^[9] ; Claire,Toquet ^[9] ; Jean-François,Mosnier ^[9] ; Solène-Florence,Kammerer-Jacquet ^[10] ; Delphine,Loussouarn ^[9]

作者单位： Department of Pathology, University Hospital of Nantes, Nantes, France. Electronic address: raphael.bourgade@gmail.com. ^[1] Laboratoire du Traitement du Signal et de l'Image - Inserm U1099, University of Rennes, Rennes, France. ^[2] Department of Radiation Oncology, Institut de Cancérologie de l'Ouest Nantes, Saint-Herblain, France. ^[3] Facility for Artificial Intelligence and Image Analysis (FAIIA), Biosit UAR 3480 CNRS-US18 INSERM, University of Rennes, Rennes, France. ^[4] Department of Medical Genetics, University Hospital of Nantes, Nantes, France. ^[5] National Institute of Health and Medical Research, Pierre Louis Institute of Epidemiology and Public Health, Sorbonne University, Paris, France. ^[6] Department of Molecular Genetics and Genomics, University Hospital of Rennes, Rennes, France. ^[7] Department of Pathology, University Hospital of Rennes, Rennes, France. ^[8] Department of Pathology, University Hospital of Nantes, Nantes, France. ^[9] Laboratoire du Traitement du Signal et de l'Image - Inserm U1099, University of Rennes, Rennes, France; Department of Pathology, University Hospital of Rennes, Rennes, France. ^[10]

关键词 BRCA mutation computational pathology deep learning high-grade ovarian cancer momentum contrast self-supervised learning segmentation

主题词人类(Humans);女(雌)性(Female);卵巢肿瘤(Ovarian Neoplasms);BRCA2蛋白质(BRCA2 Protein);BRCA1蛋白质(BRCA1 Protein);突变(Mutation)

DOI 10.1016/j.modpat.2023.100304

PMID 37580018

发布时间 2023-11-24

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