换一批
换一批Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target.
第一作者：
Johan,Vande Voorde
第一单位：
Cancer Research UK Beatson Institute, Glasgow, UK. j.vandevoorde@beatson.gla.ac.uk.
作者：
Johan,Vande Voorde [1]
;
Rory T,Steven [2]
;
Arafath K,Najumudeen [3]
;
Catriona A,Ford [3]
;
Alex,Dexter [2]
;
Ariadna,Gonzalez-Fernandez [2]
;
Chelsea J,Nikula [2]
;
Yuchen,Xiang [4]
;
Lauren,Ford [4]
;
Stefania,Maneta Stavrakaki [4]
;
Kathryn,Gilroy [3]
;
Lucas B,Zeiger [5]
;
Kathryn,Pennel [6]
;
Phimmada,Hatthakarnkul [6]
;
Efstathios A,Elia [2]
;
Ammar,Nasif [2]
;
Teresa,Murta [2]
;
Eftychios,Manoli [4]
;
Sam,Mason [4]
;
Michael,Gillespie [5]
;
Tamsin R M,Lannagan [3]
;
Nikola,Vlahov [3]
;
Rachel A,Ridgway [3]
;
Colin,Nixon [3]
;
Alexander,Raven [3]
;
Megan,Mills [3]
;
Dimitris,Athineos [3]
;
Georgios,Kanellos [3]
;
Craig,Nourse [6]
;
David M,Gay [7]
;
Mark,Hughes [3]
;
Amy,Burton [2]
;
Bin,Yan [2]
;
Katherine,Sellers [8]
;
Vincen,Wu [4]
;
Kobe,De Ridder [9]
;
Engy,Shokry [3]
;
Alejandro,Huerta Uribe [3]
;
William,Clark [3]
;
Graeme,Clark [3]
;
Kristina,Kirschner [6]
;
Bernard,Thienpont [9]
;
Vivian S W,Li [10]
;
Oliver D K,Maddocks [6]
;
Simon T,Barry [11]
;
Richard J A,Goodwin [12]
;
James,Kinross [4]
;
Joanne,Edwards [6]
;
Mariia O,Yuneva [10]
;
David,Sumpton [3]
;
Zoltan,Takats [13]
;
Andrew D,Campbell [3]
;
Josephine,Bunch [14]
;
Owen J,Sansom [15]
作者单位：
Cancer Research UK Beatson Institute, Glasgow, UK. j.vandevoorde@beatson.gla.ac.uk.
[1]
National Physical Laboratory, London, UK.
[2]
Cancer Research UK Beatson Institute, Glasgow, UK.
[3]
Department of Metabolism Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.
[4]
Cancer Research UK Beatson Institute, Glasgow, UK.;School of Cancer Sciences, University of Glasgow, Glasgow, UK.
[5]
School of Cancer Sciences, University of Glasgow, Glasgow, UK.
[6]
Cancer Research UK Beatson Institute, Glasgow, UK.;School of Cancer Sciences, University of Glasgow, Glasgow, UK.;Københavns Universitet, BRIC, Copenhagen, Denmark.
[7]
The Francis Crick Institute, London, UK.;Rheos Medicines, Cambridge, MA, USA.
[8]
Department of Human Genetics, University of Leuven, KU Leuven, Leuven, Belgium.
[9]
The Francis Crick Institute, London, UK.
[10]
Bioscience, Early Oncology, AstraZeneca, Cambridge, UK.
[11]
Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.;Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
[12]
Department of Metabolism Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.;Biological Mass Spectrometry, Rosalind Franklin Institute, Didcot, UK.
[13]
National Physical Laboratory, London, UK.;Department of Metabolism Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.;Biological Mass Spectrometry, Rosalind Franklin Institute, Didcot, UK.
[14]
Cancer Research UK Beatson Institute, Glasgow, UK. o.sansom@beatson.gla.ac.uk.;School of Cancer Sciences, University of Glasgow, Glasgow, UK. o.sansom@beatson.gla.ac.uk.
[15]
主题词
动物(Animals);人类(Humans);小鼠(Mice);腺苷高半胱氨酸酶(Adenosylhomocysteinase);结直肠肿瘤(Colorectal Neoplasms);代谢组学(Metabolomics);突变(Mutation);原癌基因蛋白质类p21(ras)(Proto-Oncogene Proteins p21(ras))
DOI
10.1038/s42255-023-00857-0
PMID
37580540
发布时间
2024-08-29
- 浏览0
Nature metabolism
Nature metabolism
2023年5卷8期
1303-1318页
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